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Biochemistry and Structural Biology

  • Program Overview

    Biochemistry and Structural Biology

    The Biochemistry and Structural Biology Graduate Program stresses biochemical, structural, and computational approaches to solving complex biological problems. Training is offered in a broad range of research areas leading to the Ph.D. degree. Research in biochemistry and structural biology includes structure-function studies of proteins and nucleic acids, the molecular basis of gene expression, the chemical basis of enzyme action, as well as membrane and carbohydrate biochemistry. The aim of structural biology is to obtain high-resolution structures of biological macromolecules and molecular complexes through experimental techniques such as nuclear magnetic resonance (NMR) spectroscopy, X-ray diffraction, and electron cryo-microscopy in order to provide a view of biology at the molecular and atomic levels. High-resolution structures combined with biochemical studies represent the blueprints for understanding enzyme catalysis, cell signaling and transport, gene expression and regulation, and numerous other cellular processes. Advances in instrumentation and computational analysis have laid the groundwork for structure determination of proteins discovered through genome sequencing efforts and have opened up structural studies on membrane proteins and large complexes of proteins and nucleic acids.

    The program includes faculty from the Departments of Biochemistry and Cell Biology, Chemistry, Applied Mathematics and Statistics, Physiology and Biophysics, and the Pharmacological Sciences, as well as from Brookhaven National Laboratory.

    For more information visit the BSB Web site at www.stonybrook.edu/biochem/bsb/.

  • Admissions

    Admission requirements of Biochemistry and Structural Biology Graduate Program

    Graduate studies in Biochemistry and Structural Biology require the following in addition to the Graduate School admissions requirements:

    A. A bachelor’s degree with the following minimal preparation: mathematics through one year of calculus; chemistry, including organic chemistry; general physics; and one year of biology.

    B. Letters from three previous instructors.

    C. Graduate Record Examination (GRE) General Test scores.

    D. Acceptance by the Graduate Program in Biochemistry and Structural Biology and by the Graduate School.

    In special cases, students not meeting all of the requirements listed in item A above may be admitted, but deficiencies must be remedied.

  • Degree Requirements

    Requirements for the Ph.D. Degree in Biochemistry and Structural Biology

    A. Course Requirements
    Core courses:

    1. Graduate Biochemistry I (MCB 520)

    2 Biomembranes (MCB 517)

    3. Computational Methods in Biochemistry and Structural Biology (BSB 515)

    4. Structural Biology and Spectroscopy (BSB 512)

    5. Cell Biology (MCB 656) or Molecular Genetics (MCB 503)

    6. Experimental Projects in Biochemistry and Structural Biology (BSB 509/BSB 510), a two-semester course in which the students spend 2-3 months in each of three different faculty laboratories actively participating in the research work of the laboratory.

    7. Enrollment every semester in Colloquium in Biochemistry and Structural Biology (BSB 601/BSB 602), a series of invited lectures by visiting scientists from other institutions.

    8. Two electives from an approved list of biochemistry, chemistry, molecular, and cell biology courses.

    9. Enrollment for one semester of Journal Club (BSB 532) in the first and second years.

    10. Enrollment for one semester of Student Seminar (BSB 603/BSB604) in the third, fourth and fifth years.

    11. Enrollment in the second year in Ethics (GRD500)

    B. Qualifying and Thesis Proposal Examination
    During their fourth semester, all students take a qualifying examination that is based primarily on their thesis proposal research.

    Each student is required to prepare and defend a research proposal based on their own research. The student prepares a detailed write up of the background and logic of the proposition, and how the research will be carried out, which then forms the basis for an oral proposition examination. Questions during the exam can cover material from the core courses and test the student’s ability to integrate basic concepts and information.  The qualifying examination and the thesis proposal examination together constitute the preliminary examination specified in the regulations of the Graduate School.

    C. Advancement to Candidacy
    When the above requirements have been satisfactorily completed, a recommendation for advancement to candidacy for the Ph.D. will be forwarded to the Graduate School.

    D. Dissertation
    During the second year, the student initiates a dissertation research project in the laboratory of a particular member of the program faculty. After the student has passed the proposition examination, a research committee is appointed to guide the dissertation research, and when the research nears completion, a dissertation examining committee is approved by the dean of the Graduate School.

    E. Dissertation Defense
    The dissertation defense, which completes the requirements for the Ph.D., consists of a public seminar presentation of the dissertation work followed by an oral examination before the dissertation examining committee.

    F. Teaching Experience
    All students in molecular biology and biochemistry, whether or not they are supported by teaching assistantships, are required to gain experience in teaching by assisting in laboratory sections, leading discussion sections, or helping to formulate and grade examination papers. The teaching experience may be in either undergraduate or graduate courses, and generally extends over a period of two semesters.

    G. Residence Requirement
    The University requires at least two consecutive semesters of full-time graduate study. The demands of the course of study necessitate a longer period of residence.

     

    Requirements for the MS in Biomedical Science

    Completion of this track will require 30 credits from the approved PhD curriculum in Biochemistry and Structural Biology and a thesis.

     

    Requirements for the MA in Biomedical Sciences

    Completion of this track will require 30 credits from the approved PhD curriculum in Biochemistry and Structural Biology and a thesis.

  • Facilities

    Facilities of Biochemistry and Structural Biology Department

    State-of-the-art facilities are available for biochemistry and structural biology. The Center for Structural Biology has several high-field NMR instruments and facilities for X-ray crystallography and electron cryo-microscopy. With close ties to the Brookhaven National Laboratory, Stony Brook takes advantage of the high-energy beam lines for diffraction studies. Throughout the program there is state-of-the-art equipment for protein purification and analysis, including Raman, infrared, fluorescence, and CD spectrophotometers. The biological sciences complex also has tissue culture facilities, a transgenic mouse facility, and a centralized Drosophila facility. These facilities are supported by a wide range of instrumentation for cell and molecular biology including transmission and scanning electron microscopes, confocal microscopes, and phosphoimagers.

  • Faculty
  • Contact

    Biochemistry and Structural Biology 

    Chairperson, Department of Biochemistry and Cell Biology
    Aaron Neiman, 450 Life Sciences Building (631) 632-8550

    Graduate Program Coordinator
    Amy Saas, 338 Life Sciences Building (631) 632-8613

    Graduate Program Director
    Steven Smith, 138 Centers for Molecular Medicine (631) 632-1210

    Degree Awarded
    Ph.D. in Biochemistry and Structural Biology; MS in Biomedical Science and MA in Biological Sciences (Biochemistry and Structural Biology tracks)

    Web Site
    http://www.stonybrook.edu/biochem/bsb/

    Application
    https://app.applyyourself.com/AYApplicantLogin/fl_ApplicantLogin.asp?id=sunysb-gs

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